In May of 2010, the National Enquirer ran a story on George Lopez having cheated on his wife with prostitutes. A professional escort, who uses the name Tiffany, told the Enquirer that in 2009 Lopez had gotten her number from a website she uses to advertise her services and that he called her to arrange a meeting at his hotel room. Tiffany said Lopez paid her $500 to have sex with him. She also said that Lopez told her he liked to use the same hookers regularly 'that way, I always know what I'm going to get'. Tiffany went on to add that she later found out he had hired a fellow hooker, by the name of Samantha, the same day he had seen her.
The prostitute passed a polygraph lie detector test she took after making these claims.
When asked to comment on having had sex with Tiffany and Samantha, Lopez denied ever having met with them.
The news of George Lopez cheating on his wife with prostitutes came as a shock, because his wife had saved his life by donating a kidney to him in 2005, after Lopez nearly died in 2004 from kidney failure.