This movie never would have seen the light of day without an A lister to head the cast as actor, writer and director. Poorly executed on every level.
1) These guys are supposed to be geniuses, but how do we know? Easy, Franco/Max reminds us of it throughout the film ("I'm a genius") and he solved a fairly easy math problem (easy for anyone who is good at math), and his brother is a surgeon. None of that really works and it makes all the other observations about how a genius deals with being a genius hollow an empty.
2) Max is the life of the party and the guy everyone likes yet the movie shows someone who is just obnoxious, cocky and annoying to watch.
3) The drug scenes dont offer anything insightful or new whereas a movie like Requiem for a Dream shows the upside and the down side of extreme drug use. Anyone who has done meth knows that if you are up for 3 days, you are down for 3 days. And the doctor using prescription drugs seems like they took that right out of Requiem with the mom and her diet pills.
4) The characters are mostly cliches, and poorly acted. It plays like amateur hour. Even Franco seems like he's reaching. And to be honest, he works best in dumb comedies (though I thought he was good in 11 23 63)
5) This movie would have worked better as a satire. Or a meth version of Pineapple Express. But it doesnt know what it wants to be and ends up falling flat on all sides as it tries to go for a deeper meaning.