To Thomas, the world meant his Appa, Amma, and his elder brother whom he calls with love 'Achacha'. When his Appa and Amma left the world, all he had was his Achacha, and Achacha being a special kid, Thomas knew he had to look after Achacha, just the way his Appa and Amma looked after him. But when he gets separated from his Achacha, Thomas had nobody else in life. The words of his relatives whom he thought wouldn't separate them betrayed him. All these years later, Thomas still has unconditional love for his elder brother. Even if the adoptive parents allow them both to see, Thomas isn't happy with the type of relationship he has with his own blood. Thomas is yearning to bring his elder brother back into his life, but Achacha's condition doesn't allow him to do so. This is the story of a Brother desperation, to bring back what could have been a perfect childhood. Thomas and Sebu, played by George Kora and Gopikrishna Verma, are two characters with a heartwarming bond that touches your heart. Throughout the movie, I laughed, I cried, and I loved all the people that come and go, thanks to the Music and Background music that elevates certain scenes that warm the audience with love and pain. Filled with small moments of happiness, sadness, and hope, Thirike tells a bitter-sweet story of two brothers on their way back to their roots and speaks out loud that children with genetic disorders are also humans and they deserve the same love, affection, and respect as everyone else.