This is definitely a forgotten piece of cinema from the early 90's if ever there was one. I found Brain Twisters as part of a recent Mill Creek DVD boxed set and, while the twelve-movie sets aren't nearly as daunting as those with fifty, when I purchase a boxed set I watch them all, no matter how painful.
In all actuality, this is not as bad as the other reviews would suggest. That's not to say this is a good movie, either; it just doesn't have anything especially interesting going on with it to fall into that So-Bad-It's-Good category. It does have some blood, but it could have used some more meat and maybe an exposed breast or two.
The basic premise is this: a college professor named Dr. Philip Rothman (Terry Londeree, in one of his only film roles--his acting is even more wooden than Keanu Reeves) is working with a private company to develop a mind-altering software, and uses his own workstudy students as lab subjects. The testing consists of the subjects watching some colorful four-bit graphics that look like they were made on a Commodore 64 or some other piece of hardware that was outdated even by the standards of the early 90's. Very pretty, yes, but in this case the colorful squares also turn the subjects into vicious killers. Sometimes they kill themselves, depending on the needs of the script.
Most of the story revolves around the life of one of Rothman's students, Laurie Stevens (Farrah Forke, who actually did go on to get some decent work on television). She's not exactly a "final girl" in any sense, though, just to note--I noticed other reviewers calling this a Slasher film, which it is not by any stretch of the imagination. Laurie is just a lead character, but she is written very thinly; she is, for example, apparently able to resist the mind control aspects of the pretty lights, but that is not very well conveyed through either script nor acting.
Behind the poorly executed plot is a conspiracy involving a video game developer (I think) that is (for some unknown reason) using the pretty light software to put into commercial games with the intention of making kids go crazy and kill people (I guess). There's also this uncomfortable romantic sub-plot with Laurie and a cop (Frank Tun, played by Joe Lombardo, whoever that is). Really, the whole thing is one big mess.
I honestly can't recommend this flick for anyone, but it was moderately amusing, if only because it was so bad.
