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House checks himself into rehab just before his trial, but a different game entirely may be afoot. Elsewhere, the team attempts to treat a firefighter who can't stop shivering.

Dr. Andrews questions whether Shaun is really ready for his first surgery; Dr. Brown and Dr. Reznick have a patient whose diagnosis has them doubting his story.

House and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.

A young girl is ailed with diseases that usually strike people much older than her 6 years of age. But before House can diagnose her, her brother starts exhibiting the same symptoms she was admitted with. During all of this House gives Wilson tickets that a patient had given to him for a play. Ensuing a discussion on why men take women to plays. Wilson decides to take Cuddy and the tug of war with House for her affections begins, although Cuddy insists that she only went with Wilson as a friend.

Shaun visits his father on his deathbed and the reunion's results are unexpected. Claire addresses her grief. An NFL player needs treatment.

A woman seeing her dead mother stumps the recruits, especially once she begins seeing a recent victim.

House is taken by jet to help diagnose a dying CIA agent, leaving Foreman in charge of the team trying to find out why a young woman passed out after a drag car race.

House and his team are hampered by a reality television crew while battling over possible diagnoses for a craniofacial surgery patient.

A magician's heart stops during a performance. At first House dismisses the case, but later changes his mind when complications arise. House has a contest to determine the next one to leave the team.

House treats a rock musician, and some of the candidates have to get past their personal biases, Wilson misdiagnoses a patient, and the winners are named.

A struggling novelist and a young waitress strike up an extramarital relationship that promises to forever change the course of their lives.

Noah, Margaret and Stacey bond over their mutual distaste for Sasha. Noah attempts to sabotage Helen and Sasha's relationship. Whitney and Colin face the hardships of their relationship. Joanie visits the graveyard.

Shaun opens up with Aaron about his feelings towards Lea.

Nika Owen is a trainee lawyer. A beginner in the world of law. And an initiator in life. Through the mysterious death of Inspector Novak, the unraveling of secrets is triggered, leading her down the path of learning what is really going on in society. Her career is at stake, her friendship, her love.

When a researcher at a South Pole base becomes ill, House must diagnose the case at a distance. Meanwhile, House tries to find out who Wilson is dating, and his new staff tries to get him cable.

A woman collapses at her wedding. She led a different life style before her marriage, House insists she hasn't changed. Wilson starts dating Amber.

House encounters a patient who is too nice for his own good, which is a bigger problem than his emergency room diagnosis; and House competes with Amber for Wilson's attention.

After Shaun treats a famous patient, he deals with unwanted attention. Carly's efforts to separate Shaun from Lea are challenged.

House finds himself at odds with his team when he becomes convinced that an actor on his favorite soap, "Prescription Passion," has a serious medical condition.

A bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.

Genius lies somewhere in the human mind, bringing mathematical insight, sparking artistic inspiration and enabling some to see what most cannot. Might we augment our biology with technology to unlock the genius inside us all?

The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.

House's preoccupation with Wilson leaves his team without direction and endangers the patient, a female whose exhaustive work schedule and demanding boss may have caused her condition.

Four soldiers slain in a military hospital put the Sniffer and the SBI on the elusive trail of a killer with grotesque facial scars who's hunting the camp goon squad.

Years after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.