- He is of English descent but lives in Texas.
- Has directed six Emmy Award-winning performances: George Hearn in Sweeney Todd: The Demon Barber of Fleet Street (1982), Betty White in The Golden Girls (1985): Season 1, Rue McClanahan in The Golden Girls (1985): Season 2, Estelle Getty in The Golden Girls (1985): Season 3, Bea Arthur in The Golden Girls (1985): Season 3, John Lithgow in 3rd Rock from the Sun (1996):: Seasons 1-2 & 4 and Kristen Johnston in 3rd Rock from the Sun (1996): Seasons 2 & 4.
- He directed the feature film The Butcher's Wife (1991), with Demi Moore playing the title role. In her 2019 memoir, Moore wrote that she didn't trust Hughes, and that her agent talked her into making the film strictly for the money. She wrote that "it was a disaster of an experience that I didn't want to repeat". The film was a critical and box office failure.
- His wife's name is Margaret, and his daughters are Emma and Sarah.
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