- Before becoming famous as an actor in Red Dwarf (1988), he was known as a dancer and singer. He performed with top music acts such as David Bowie and Wham!.
- In season 5, episode 6, of _"Death in Paradise" (2011), Danny's character, Officer Dwayne Myers, deals with a young scamp named Jackson. Jackson was played by Danny's son, Danté Langlais-John-Jules.
- He appeared in "Little Shop of Horrors," singing with a group of other people at a bus stop.
- His nephew (not son, as some have reported) Alexander John-Jules played Lister as a baby in Ouroboros (1997).
- In the Family Guy episode "Road to Germany" there is a reference to the "Total Eclipse of the Sun" song in "Little Shop of Horrors", and an animated character based on Danny John-Jules's background performance can be seen briefly, alongside animated characters based on the other dancers.
- He is the son of Dominican parents.
- He was a member of the original cast of the London production of Starlight Express at the Apollo Victoria Theatre playing the role of Rocky I - a box car.
- He is the father (with fiancée Petula Langlais) of Danté Langlais-John-Jules and Danaè Langlais-John-Jules.
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