- He nearly died in 1988 from injuries suffered making The Karate Kid Part III (1989).
- In 1995, six years after making The Karate Kid Part III (1989) (in which he performed most of his own stuntwork), he made a public appearance at the Eagle Rock Plaza in Southern California. The first person in Kanan's autograph line asked him to sign "Mike Barnes," following Sean's own name. Kanan happily obliged; according to himself, it was the first time he had ever been asked for an "autograph" from his KK3 character.
- Laughingly refers to Mike Barnes, his character from The Karate Kid Part III (1989), as "Johnny to the Tenth Power".
- Sean is extremely well known in Italy and speaks Italian.
- He is of mostly Russian Jewish and Lithuanian Jewish descent.
- Collects baseball cards from the 1940s and 1950s.
- During Christmas 1999, he accompanied Christie Brinkley and Al Franken as guests of Secretary of Defense William Cohen, to Bosnia and Kosovo where they entertained U.S. troops.
- He is related to former on-screen brother, Steve Burton, by marriage.
- Has a daughter, Simone Andrea Kanan (b. late 2001), with former co-star on The Bold and the Beautiful (1987), Gladise Jiminez. Simone lives with her mother, but Sean is very much a part of her life.
- Sean has a degree in Political Science from UCLA.
- Was a bouncer at Father's, a bar in Boston.
- Authored "Success Factor X" which was named one of the twenty best inspirational books of the last two decade by Book Authority.
- Graduated Mercersburg Academy in Mercersburg, Pennsylvania, 1985; school also attended by James Stewart, 1927-1928.
- Attended Boston University where he majored in Political Science.
- Authored "The Modern Gentleman: Cooking and Entertaining with Sean Kanan.
- Has a black mini pug. Her name is Charli Kanan and has appeared in several onscreen projects with Sean.
- Attended Boston University for two years before graduating from UCLA with a B.A. in political science.
- Former brother-in-law of Alanna Ubach.
- Born on the same day as David Schwimmer.
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