- Prime minister of the United Kingdom (10 January 1957 to 18 October 1963).
- Son of an American mother and a British father.
- His grandfather and great uncle were the sons of crofters from Arran Island but formed Alexander Macmillan and Co, the publishing company.
- His wife was the daughter of the 9th Duke of Devonshire.
- Created Earl of Stockton and Viscount Macmillan of Ovenden by Queen Elizabeth II in 1984 after years of refusing a peerage.
- He is the subject of the play 'Never So Good' by Howard Brenton which premiered at the National Theatre in London, UK in March 2008. In the original production he was portrayed by Jeremy Irons.
- British Minister of Defense (19 October 1954 to 7 April 1955).
- British Foreign Secretary (7 April 1955 to 20 December 1955).
- As Chancellor of the Exchequer he opposed publishing a report linking cigarette smoking to lung cancer in 1956. The report was not published until 1964.
- He was largely to blame for the failure of the Anglo-French invasion of Egypt during the Suez Crisis.
- His real first name "Maurice" is pronounced "Morris" (as in the traditional U.K. way).
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