- She was the first caller to Jean Shepherd's late-night radio program on WOR-AM. He answered the call on the air and she became a frequent guest, known to listeners as "The Caller". Together, they created the call-in radio show.
- Was making up her own mini-plays and acting them out in her backyard at age 7.
- Although a native of the Chicago area and a long-term California resident, Nettleton is buried at Saint Raymond's Cemetery in The Bronx, New York.
- Was nominated for Broadway's 1976 Tony Award as Best Actress (Featured Role - Play) for "They Knew What They Wanted."
- The daughter of Edward and Virginia Nettleton, Lois Nettleton was Miss Chicago 1948 and a semi-finalist at the 1948 Miss America pageant.
- In 1959, Nettleton won a Clarence Derwent Award for Best Supporting Performance by a non-featured actress for "God and Kate Murphy".
- Attended the 2006 Twilight Zone Convention at the Hilton Hasbrouck Heights, Hasbrouck Heights, New Jersey, August 12-13, 2006.
- Attended the 2007 Twilight Zone Convention at the Hilton Hasbrouck Heights, Hasbrouck Heights, New Jersey, August 4-5, 2007.
- She was a lifelong liberal Democrat.
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