- One of the 36 founders of the Academy of Motion Picture Arts and Sciences (AMPAS)
- Born Frederick Liedtke, he changed his last name to Niblo in the early 1900s when he was performing in vaudeville and one of the theaters he worked the most was owned by a man named William Niblo.
- Stage and vaudeville actor.
- Wife, actress Josephine Cohan, was the sister of George M. Cohan.
- Has a Star on the Hollywood Walk of Fame on the 7000 block of Hollywood Blvd.
- He has directed two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: The Mark of Zorro (1920) and Ben-Hur: A Tale of the Christ (1925).
- Children, with Enid Bennett: Louise, Peter and Judith.
- Child, with Josephine Cohan: director Fred Niblo Jr..
- On May 24, 1926, he served as Master of Ceremonies at the ground christening for construction of the famed Roosevelt Hotel in Los Angeles. The hotel, which hosted the first Oscar ceremony, opened one year later.
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