- Has a tattoo down her left side, which was supposed to say "Live without regrets" in Italian. Ironically, it is misspelled.
- Along with other protesters including Isabel Lucas, she paddled out on surfboards to a pod of dolphins off the coast of Taiji/Japan to protest the killing of dolphins on 11/1/07. This action is mentioned in the documentary The Cove (2009).
- Her last name is pronounced "Pan-Hey-Tee-Air" and is the Italian translation of "Baker". Her parents are both of half Italian descent (her father's father and her mother's mother were both the children of Italian immigrants). Her other roots include German and English.
- Had a partnership with US Postal Inspection Service and the National Center For Missing And Exploited Children in a campaign against online predators, called 2 SMRT 4U.
- Elder sister of Jansen Panettiere, with whom she co-starred in Tiger Cruise (2004). Hayden considers him "the greatest present our dad and mom ever gave me".
- Began her acting career at 11 months when she appeared in a commercial for Playskool.
- While making Racing Stripes (2005) in South Africa, she was bucked off a zebra and ended up in the hospital with a concussion, whiplash and two compressed vertebrae in her neck.
- On Guiding Light (1952) (1998-2000), for her character Lizzie's battle with leukemia, the show received a Special Recognition Award, from The Leukemia and Lymphoma Society, for bringing national awareness of the disease to the attention of daytime viewers.
- Mother, Lesley Vogel-Panettiere, doubles as her manager.
- Hobbies include singing, dancing, horseback riding, gymnastics, and swimming.
- Has appeared in over 50 commercials.
- Returned to work five months after giving birth to her daughter Kaya to begin filming Custody (2016).
- 2000: Was nominated for a Grammy for Best Spoken Word Album for Children for A Bug's Life (1998) Read-Along.
- She is the second-ever recipient of The Wyler Award (which honors a celebrity who has raised awareness of animal issues) for her on-the-ground work to expose Japan's slaughter of dolphins.
- Has two dogs, named Penny Lane and Madison.
- Was originally cast to play Sarah Altman in Panic Room (2002) but was later replaced by Kristen Stewart.
- As of December 2004 was living in Palisades, NY, where she grew up.
- In 2007" Forbes" Magazine estimated her earnings for the year at $2 million.
- Parents are: Lesley Vogel, a former soap opera actress; and Alan L. Skip Panettiere, a fire department lieutenant. Coincidentally, her first rescue on Heroes (2006) was from a train wreck fire.
- In March 2008 was ranked #1 on "Wizard" magazine's "Sexiest Women of TV" list.
- Was considered for the role of Ariel Moore in Footloose (2011) along with Miley Cyrus, and Amanda Bynes. She ultimately lost out on the role to Julianne Hough.
- In 2000 was Childstarlets.com's Actress of the Year.
- Was in an on-off relationship with Wladimir Klitschko from 2009 to 2018. In October 2013, it was announced they were engaged. They have a daughter together.
- On 7/21/98 was named "Soap Opera" Magazine's star of the week.
- Sebastian Stan portrayed her character's brother in The Architect (2006), and he portrayed her boyfriend in Hayden Panettiere: Wake Up Call (2008), one of her music videos.
- Her last name was printed wrong in an issue of the "Discovery Girls" magazine where she was considered an "Exceptional Tween".
- Ranked #11 in "FHM"'s "Sexiest Women" list in 2008.
- Voted #6 in "FHM" 100 Sexiest 2007.
- Was ranked #30 on "Maxim" magazine's Hot 100 Women of 2010 list.
- Ranked #12 in the 2010 "FHM" UK list of "100 Sexiest Women in the World".
- Ranked #13 on the "Maxim" Hot 100 of 2008 list.
- Ranked #21 in the 2011 "FHM" list of "100 Sexiest Women in the World".
- Voted #5 in "FHM" 100 Sexiest 2008.
- Ranked #26 on "Maxim"'s "Hot 100" of 2014 list.
- She loves bathing suits and never has a problem with wearing one for the camera.
- Born at 9:20 AM.
- Mentioned in My Whole Life Is Thunder (2012).
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