- After years of drug-induced tension with his bandmates, most notably lead singer Steven Tyler, he left Aerosmith in 1979 after a backstage incident in Cleveland where his first wife, Elyssa, poured milk on Tom Hamilton's wife, Terry.
- Is of Portuguese/Italian descent. His father's family were Portuguese immigrants from the Island of Madeira and his mother's family came from Naples (Italy).
- After leaving Aerosmith, started the "Joe Perry Project", which released three albums with minimal commercial success. Was auditioning to be the guitarist for Alice Cooper when he and Brad Whitford decided to re-join Aerosmith in 1984.
- In 2015 Joe Perry, Alice Cooper and Johnny Depp formed the band Hollywood Vampires. The name of the band was derived from "The Hollywood Vampires", a celebrity drinking club that was formed in the 1970s by Alice Cooper that included members such as Ringo Starr of The Beatles and Keith Moon of The Who.
- Lead guitarist with Aerosmith.
- He met wife Billie Paulette Montgomery in June of 1983 during the filming of his video "Black Velvet Pants" with the Joe Perry Project. He married her at the Iao needle in Maui, HI, on 9/21/85.
- Inducted into the Rock and Roll Hall of Fame in 2001 (as a member of Aerosmith).
- Has a younger sister named Anne-Marie (b. 12/54).
- A long-time connoisseur of spicy foods, he formulated his own brand of hot sauces called "Rock Your World," in habanero pepper ("The Boneyard") and peach mango ("Mango-Peach Tango") flavors. Both first appeared in 2005 after a year of development with Boston-based Ashley Foods, Inc.
- His sister-in-law, Diana "Dee" Minor, is pool player in the VNEA international Hall Of Fame and a top-ranking member of the WPBA for many years.
- Went to Wayland High School and performed with Aerosmith at the field house. There is a picture of he and Steven Tyler on stage hanging in the field house.
- Lives in Duxbury, MA.
- Grew up in Hopedale, MA. He formed a high school band called Chimes of Freedom.
- His first wife, Elyssa Jerret, is the daughter of jazz clarinetist Nick Jerret. Jerret had his own big band but also worked with Billie Holiday and Dizzy Gillespie.
- Sons: Adrian Perry (with Elyssa) Tony and Roman Perry(with Billie) Stepson Aaron Hirsch (from Billie's first marriage)
- Joe's stepson, Aaron, is the CEO for his hot sauce brand, the Joe Perry's Rock Your World. Aaron, married to Becky, has a little son called Austin.
- In 2015 he, as part of Hollywood Vampires, released an album, "Hollywood Vampires", with fellow band members Alice Cooper and Johnny Depp. The album featured guest appearances by Dave Grohl, Paul McCartney and Christopher Lee.
- On 5/24/16 he, as part of Hollywood Vampires, embarked on their first concert tour across Europe.
- He is a lifelong supporter of the Republican Party.
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