- The last television series Rhue appeared on was Murder, She Wrote (1984), in which she played the recurring character of a librarian. Series star Angela Lansbury reportedly had heard that Rhue was in danger of losing her Screen Actors Guild medical coverage because she was short of meeting the annual earnings requirement. Lansbury created the librarian character for Rhue and brought her in every three or four episodes so she could meet the requirements.
- Besides playing Ricardo Montalban's love interest in Space Seed (1967), she also played his wife in Day of Reckoning (1960).
- Passed away one year after her former husband Tony Young, who died from lung cancer on February 26, 2002.
- Both Rhue and her former husband, Tony Young, were guest stars on Star Trek (1966). He was with France Nuyen in Elaan of Troyius (1968) and she was Ricardo Montalban's character's (Khan Noonien Singh), love interest in Space Seed (1967).
- After going public with her multiple sclerosis, she was asked to participate in a National Multiple Sclerosis Society ad campaign. She initially turned it down, telling the Los Angeles Times that she had thought that the organization wanted her to do what she called "poor me" ads. She changed her mind after learning that the campaign would feature people with MS doing everything from scuba diving to skydiving. The 1988 ad showing Rhue in her wheelchair noted that she "can't walk so well anymore, but she can still perform." It was headlined "Even with MS, Madlyn Rhue is on a roll". Her illness prevented her from reprising her role as Marla McGivers (Khan's wife) in Star Trek II: The Wrath of Khan (1982).
- Was close friends with Suzanne Pleshette and Faye Michael Nuell.
- After landing the role in Houston Knights (1987), she placed a full-page ad in Variety magazine headlined "See the new Madlyn Rhue".
- Attended and graduated from Los Angeles High School in Los Angeles, California, the oldest high school in California. Later, she attended Los Angeles City College, where she studied drama.
- Best remembered by the public for her role as Lieutenant Marla McGivers in the first season episode Space Seed (1967).
- Was a conservative Republican who supported the presidencies of Richard Nixon, Gerald Ford, Ronald Reagan, George Bush and George W. Bush.
- During her appearance on Carl Reiner/David Brenner/Madlyn Rhue/Burt Mustin (1974), she said she is half Jewish, half Catholic.
- Ex-daughter-in-law of Carleton G. Young.
- Appeared with her then-husband Tony Young in the film "He Rode Tall".
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