- After graduating from Dartmouth, she read a news article that claimed that getting into USC's film school was harder than getting into Harvard Law School, so she elected to take on the more competitive challenge.
- Rhimes is the youngest of six children of a PhD teacher/mother and a father who is now chief information officer at the University of Southern California.
- Has 3 daughters: two adopted daughters are named Harper Rhimes (b.2002) & Emerson Pearl Rhimes (b.February 1, 2012) and another one daughter named Beckett Rhimes (b.September 2013) who was born via surrogate mother.
- On the first day in September 2001 that she moved into a rental house in Vermont as a quiet place to finish a movie script, the World Trade Center was attacked, which prompted Rhimes to reassess her future and her goals. She decided her top priority was to adopt a child and nine months later she did, with daughter Harper, and became a single mother. Emerson followed in 2012.
- Maintains two rooms across from her studio for her two children.
- She has a bachelor's degree from Dartmouth (1991) and a master of fine arts (MFA) from the University of Southern California's School of Cinema-Television.
- In 2013, she and her Shondaland company partner Betsy Beers were named co-winners of the 2014 Directors Guild of America Diversity Award.
- Suffers from fear of public speaking (glossophobia).
- Her professional output is responsible for an estimated 70 hours of television per season.
- Worked for few years as a film-development assistant before selling her first script.
- She is the youngest in her family and has three sisters and two brothers.
- Shed 117 lbs in a weight loss program. (2016)
- Is a big fan of Game of Thrones (2011).
- Interned for producer Debra Martin Chase while attending USC.
- Born on exactly the same date as Keith Coogan.
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