- Her one-woman play "My Big Fat Greek Wedding" was turned into a movie after Rita Wilson saw the play and recommended it to her husband Tom Hanks.
- Married NY-born TV actor Ian Gomez in Winnipeg's St. Demetrios Greek Orthodox Church.
- Her parents are both of Greek descent.
- She and her ex-husband Ian Gomez adopted a little girl named Illaria (b. 2007) in 2008.
- Became a naturalized U.S. citizen on April 20, 1999.
- Named after her grandmothers Eugenia and Antonia.
- Graduated from Ryerson University's School Of Acting.
- Is an alumna of The Second City.
- She was nominated for a 1994 Joseph Jefferson Award for Actress in a Revue for "Whitewater for Chocolate", at the Second City Theatre in Chicago, Illinois.
- (July 3, 2018) Filed for divorce from her husband of nearly 25 years Ian Gomez following a 12-month-long separation.
- Once worked the box office at Toronto's Second City.
- Nia and her Connie and Carla (2004) co-star, Toni Collette, have the same full first name, Antonia.
- She was awarded the 2002 Queen Elizabeth II's Golden Jubilee Medal from the Canadian Governor General. She lives in Los Angeles, California, United States.
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