Trivia

His self-described 'crooked mouth' is a result of dead nerves, which cause the left side of his mouth to remain immobile.

Boyfriend of Gilmore Girls (2000) co-star Alexis Bledel from 2002 to July 2006.

He was awarded a Star on the Hollywood Walk of Fame for Television at 6562 Hollywood Boulevard in Hollywood, California on January 10, 2022. Producer Amy Sherman-Palladino and Jon Huertas were guest speakers at the ceremony. His Walk of Fame star is located in front of The Hollywood Partnership.

Starred as Fergie's love interest in her music video "Big Girls Don't Cry". (June 2007)

Milo and Heroes (2006) co-star Adrian Pasdar auditioned for roles in the proposed Gilmore Girls spin-off where Milo was to be the son of Pasdar's character. As there is only 12 years difference between them, the casting director said they would be better off playing brothers. Eight years later, they were playing brothers Peter (Milo) and Nathan (Pasdar) Petrelli in Heroes (2006).

Ventimiglia took a United Service Organization (USO) tour from July 6 to 12, 2008 in support of American troops in Kuwait, Iraq and Afghanistan.

In 2003 he co-founded (with Russ Cundliff, formerly of the William Morris Agency) a production company called Divide Pictures.

The role of Chris Pierce on American Dreams (2002) was written specifically for him after he met with the show's creators.

Boyfriend of Heroes (2006) co-star Hayden Panettiere from December 2007 to February 2009; the press dubbed them "Haylo".

His favorite book is the horror novel "The Long Walk" (Stephen King, firmed with the pseudonym of Richard Bachman).

Starred in a season three episode of Gilmore Girls (2000), which was the backdoor pilot for a California-set spin-off titled "Windward Circle", that was to have starred Ventimiglia, Sherilyn Fenn and Rob Estes. The network dropped the project citing cost issues due to filming on location in Venice, California.

Similar to his fellow Gilmore Girls (2000) cast, also donates to the Pediatric Brain Tumor Foundation, one of his favorite charities.

Directed the 2003 and 2004 WB Image Campaigns for popular shows such as Gilmore Girls (2000), One Tree Hill (2003), 7th Heaven (1996), etc... Some of the WB stars he directed included David Boreanaz, Tom Welling, Kristin Kreuk, Michael Rosenbaum, Jamie Kennedy, James Marsters, Rose McGowan, Allison Mack, Chad Michael Murray, James Lafferty, Beverley Mitchell and Reba McEntire.

His father is of Italian (Sicilian) descent. His mother is of English and Scottish ancestry; half of her family is most recently from the American South, while the other half is composed of recent immigrants from England and Scotland (by way of Canada).

His favorite bands are The Clash, The Smiths, The Strokes, Deftones, A Tribe Called Quest and The Hives.

Has two older sisters, Leslie and Laurel, born circa 1973 and 1975.

Attended and graduated from El Modena High School in Orange, California (1995).

Has a 1967 Chevelle Supersport named "Evelyn".

He landed his first movie audition at age 12, for the role of Mike in Radio Flyer (1992). Out of the 3,000 candidates, he was one of eight finalists for the role before Elijah Wood was cast.

Close friends with Adrian Pasdar and Sophia Bush.

Nominated for the 2018 Emmy Award in the Lead Actor in a Drama Series category for his role as Jack Pearson in This Is Us (2016), but lost to Matthew Rhys from The Americans (2013).

He landed his second movie audition at age 16, during a cattle call for the role of Robin/Dick Grayson in Batman Forever (1995) and Batman & Robin (1997). The role went to Chris O'Donnell.

Made his debut in Bourgie Sings the Blues (1995).

Is a staunch liberal Democrat who was financially active in the campaign and election of Barack Obama in 2008. Through his production company, Divide Pictures, he donated $6,900 to Obama for America and then $2,500 to the Obama Victory Fund.

Played Jess Mariano on Gilmore Girls (2000) and ended up marrying a woman whose last name is Mariano.

No relation to actor John Ventimiglia.

Has dual Italian and American citizenship.