- Longtime friend of Luke Perry.
- Transitioned into a woman in 2006, but since 2013 until his death in 2016, he was living as a man again. According to his brother David Arquette, Alexis said to him that he alternately felt like a man or a woman at different times.
- Was cast as the "Young Boy" in The Tubes' "She's a Beauty" video because she happened to be on the set that day.
- Appearing on the 6th installment of The Surreal Life (2003) on VH-1. (March 2006)
- Alexis is also an L.A. area underground cartoonist, her most famous strip was called "Nico's Mobile Mole" and was about her friend, actress Nico Petrakis.
- The family surname was spelled "Arcouet" many generations back. Her father had French-Canadian, English, Swiss-German, German, Scottish, Irish, and Welsh ancestry. Alexis's maternal grandfather, Yusseff "Joseph" Nowack, was a Jewish immigrant from Bila Zerkwa, Kiev, then in the Russian Empire, while Alexis's maternal grandmother, Claire Hibel, was born in New York, to Russian Jewish parents.
- Former sister-in-law of actors Nicolas Cage, and Thomas Jane who were married to her sister, Patricia Arquette. Former sister-in-law of Tony Greco, James Newton Howard and John Sidel, who were married to her sister, Rosanna Arquette. Former sister-in-Law of Courteney Cox, who was married to her brother, David Arquette.
- Daughter of Lewis Arquette and Brenda Denaut. Sister of Richmond Arquette, David Arquette, Patricia Arquette, and Rosanna Arquette. Granddaughter of Cliff Arquette and Julie Harrison. Aunt of Zoë Bleu Sidel (Rosanna's daughter), Enzo Rossi and Harlow Jane (Patricia's children), Coco Arquette, Charlie West & Augustus Alexis Arquette (David's children).
- Sister-in-law of Todd Morgan, Rosanna's 4th husband. Sister-in-law of Christina McLarty Arquette, David's second wife.
- Arquette posed as the Hindu god Krishna for a controversial cover for Genre Magazine (a gay men's publication).
- Never publicly revealed if she had gotten Sex-Reassignment Surgery.
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