- Annette used her knack for knitting to raise funds for the Maryland chapter of the Alzheimer's Association. She designed an afghan blanket which was auctioned off on eBay. She and her fellow Smallville (2001) cast and crew members knitted the squares that made up the blanket. Also, she participated in a similar project with other celebrity knitters to raise funds for those affected by the 9/11 tragedy.
- Co-wrote Oscar-nominated song "A Kiss At The End Of The Rainbow" for A Mighty Wind (2003) with husband Michael McKean. The couple performed their version when they were presenters at the 8th Annual Art Directors Guild Awards in Beverly Hills in 2004, as well as during TV and radio appearances.
- Played Clark Kent's teenage sweetheart, Lana Lang, in Superman III (1983), and his (adoptive) mother, Martha Kent, in Smallville (2001).
- She plays the mandolin.
- She has two daughters from her first marriage. Their names are Nell Geisslinger and Anna Geisslinger.
- Inducted into the Texas Film Hall of Fame on March 7, 2013 in Austin, Texas.
- Has resumed her career as a stage actress during the past few years. She has performed in productions of new and classic works. Even recorded a play for radio.
- Is one of a hundred celebrities featured in a cookbook of southern recipes that benefits a literacy center in Georgia.
- Is a member of the Academy of Television Arts and Sciences.
- Is heading back to New York's Playwrights Horizons Theater Company to play the lead role in "Kindness," a new play by Adam Rapp. O'Toole's character is a mother from Illinois who heads to Manhattan with her teenage son. The mother is a victim of a bad marriage and poor health. Rapp will direct Annette in the production this fall. (June 2008)
- She has English, Irish, Scottish, Bohemian (Czech), and Cajun ancestry. Her matrilineal great-grandmother, Mary Elizabeth Matejowsky, was a Bohemian/Czech immigrant.
- Stepmother of Colin McKean and Fletcher McKean.
- Will be singing "A Kiss At The End Of The Rainbow" with husband Michael McKean during several dates as part of the "Unwigged & Unplugged" tour. That event involves the members of Spinal Tap. (April 2009)
- She made guest appearances on both of the longest-running prime time dramas in US television history: Gunsmoke (1955) (in 1970) and Law & Order (1990) (in 2000).
- Is in rehearsals to play the character of Lily Forrest in "Magnolia," a new play by Regina Taylor. The play will run at Chicago's Goodman Theater from March 14th through April 19th. (February 2009)
- Was in an 8-year relationship with Bruno Kirby.
- Is in rehearsals for an Off-Broadway revival of Anton Chekhov's "The Seagull" at New York's Classic Stage Company. She plays the role of Paulina. The production begins sneak previews on February 20th. It opens March 13th. It closes March 30th. (January 2008)
- Her limited engagement as Paulina in the Classic Stage Company's Off-Broadway revival of "The Seagull" has been extended to close April 13th instead of March 30th in New York City. (February 2008)
- In the comics, the two Superman characters she has played Martha Kent and Lana Lang are 5' 4". This is her height in real life.
- Studied acting with Peggy Feury at the Loft Studio in California.
- A favorite of critic Pauline Kael, who singled out her performance in Cat People (1982) as one of its redeeming features. Fellow critic Stephanie Zacharek recalled that, on first meeting her, Kael exclaimed delightedly, "You have Annette O'Toole's hair!".
- Vickie Howell, the host of Knitty Gritty (2004), the cable TV show, named a scarf for Annette. It's called the Lana And Clark Ascot.
- Has been mentioned in four Jeopardy! (1984) categories: Superman, Country Music, TV Shows By Cast and They All Played Country Singers.
- In an interview with Michael Rosenbaum, she admitted that she was a fan of Superman comic book as a kid.
- Almost substituted for Parker Posey during a 2003 concert tour that was done in connection with A Mighty Wind (2003).
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