- In his first marriage, with Rocky Parker, he had a stepson who is a year older than he is.
- As a teenager growing up in Maine, he was a state champion downhill skier who trained for a place on the Olympic team.
- As a teenager, placed third in his age group at the National Jugglers Convention. Aspired to attend Clown College.
- His first wife, Rocky Parker, is the mother of his best friend, actor Corey Parker, and Noelle Parker.
- At the time of his first marriage, he was 21 and his bride was 48.
- Auditioned for the role of "Dr. Gregory House" on House (2004).
- Driver of Pace Car at 91st Indianapolis 500; May 27, 2007.
- Jillian Dempsey filed for divorce in January 2015. The couple confirmed that they are back together a year later, in January 2016.
- Then-wife Jillian Dempsey, gave birth to twin boys, Darby Galen Dempsey and Sullivan Patrick Dempsey, on February 1, 2007.
- Currently co-owner of Indycar Series team Vision Racing (February 2006)
- Tried out for the role of Duckie in Pretty in Pink (1986).
- Daughter, Tallula Fyfe Dempsey (born February 20, 2002) with then-wife Jillian Dempsey.
- Enjoys collecting antiques, remodeling homes, and skiing in his spare time.
- His team, Dempsey Racing, finished second in the 2015 24 hours of Le Mans.
- On his father's side, Patrick has German, English, Scottish, and distant Swedish, ancestry. Patrick's father was born with the surname "Schlossnagle", and later took his own stepfather's surname, "Dempsey".
- Dempsey is known to have a collection of sports and collector cars.
- Visited Sao Paulo, Brazil for the launch of his second fragrance Patrick Dempsey 2, exclusive for Avon. (May 2010)
- Attended St. Dominic's Regional High School in his hometown of Lewiston, Maine.
- Patrick Dempsey trained in the Meisner technique with Joanne Baron.
- Lived in Buckfield, Maine, and attended Buckfield High School.
- Voted #13 in Elle (France) Magazine's "15 Sexiest Men" poll (June 2007).
- Driving a Panoz GTS race car in the Panoz GT Pro Racing Series. He was seen participating in race #2 of the 2004 racing season at the Mid-Ohio Sports Car Course on June 27, 2004. (June 2004)
- Chosen by People Magazine as the Sexiest Man Alive in 2023.
- (May 20, 2008) Visited Amsterdam during the European promotion tour for Made of Honor (2008).
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