- Considered by director/producer Garry Marshall to be his "good luck charm", and as such is offered a role in each of his movies. Appears in so many Garry Marshall films that his credit in the beginning of Exit to Eden (1994) was "As Usual... Hector Elizondo".
- Got the role in Pretty Woman after Al Pacino turned it down.
- Hector is a fine guitarist and singer. Wife Carolee Campbell is a noted bookbinder, photographer and actress.
- He has played the same character (Dr. Phillip Watters) on three different television series: Picket Fences (1992), Chicago Hope (1994) and Early Edition (1996).
- He is the only surviving member of the gang in The Taking of Pelham One Two Three (1974).
- Hector received a Tony for his role in Bruce Jay Friedman's "Steambath".
- Is the only actor to appear in every episode of Chicago Hope (1994).
- Turned down the role of Arturo in Sliders (1995) because it was being filmed in Canada.
- Best known by the public for his starring role as Dr. Phillip Watters on Chicago Hope (1994).
- Has a son from a previous marriage named Rod. He also has a granddaughter named Juliette.
- Acting mentor of Peter Berg and Jayne Brook.
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