- She flew to New York City every weekend during the run of The Brady Bunch (1969) (which filmed in Los Angeles) in order to be with her family.
- Could sing 50 songs by heart by the age of 2.
- In the mid-1950s, she was diagnosed with a bone deformation of the inner ear, and she had to have surgery to prevent deafness.
- Was the first woman to be a guest host of The Tonight Show Starring Johnny Carson (1962).
- In a 2006 TV Guide/Bravo poll, her Carol Brady character was named the TV mom that most shaped viewers perceptions of a housewife with 45% of the vote. She topped both June Cleaver (Barbara Billingsley from Leave It to Beaver (1957)), and Shirley Partridge (Shirley Jones from The Partridge Family (1970)) for the honor.
- She was widowed due to the death of her second husband, Dr. John Kappas, who was a hypnotherapist. He and Florence met when he helped her battle depression during the mid-1980s. He also helped to train her in hypnotherapy, enabling her to pass the state exam and become a California state licensed hypnotherapist.
- Florence filed lawsuits against two companies because of the unauthorized use of her photo - Serial Killer, Inc. had been using her face on a t-shirt with the name "Porn Queen" underneath. A gift shop in Cotati, California also used her picture in an ad. (May 1999)
- Was a licensed hypnotherapist. She learned about hypnotherapy from her late husband, John Kappas.
- Was a Today (1952) girl from 1959-1960, and later went on to co-host the short lived spin-off series Later Today (1999) from 1999-2000.
- Youngest of 10 children born to an Indiana tenant farmer, Joseph Robert Henderson, and his homemaker wife, Elizabeth Pauline "Bessie" (Elder). Her parents were originally from Kentucky.
- Four children with her first husband, Ira Bernstein: Barbara Bernstein, Joseph Bernstein, Bob Bernstein and Elizabeth Bernstein.
- Graduated from Indiana's St. Frances School (1951), and then studied at the American Academy of Dramatic Arts (AADA) in Manhattan, New York City. She earned a scholarship to AADA because of her singing talent.
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