- (October 20, 2018) Was diagnosed with multiple sclerosis on August 16th this year. She probably had this disease for at least 15 years before being diagnosed.
- Uses a cane while walking due to multiple sclerosis.
- (February 26, 2019) Has spasmodic dysphonia, which affected her voice.
- Her mother was a judge and her sister was a police officer for 11 years.
- Throughout high school she disliked her first name and went by just Blair.
- Wore a pale pink wedding dress for her wedding and had an identical dress made in black for the reception.
- Developed a fear of the water and sharks after seeing Jaws (1975).
- Audtioned for the role of Buffy on the TV show Buffy the Vampire Slayer (1997) which eventually went to Sarah Michelle Gellar, whom she appeared opposite in Cruel Intentions (1999).
- She has a one-eyed dog named Wink.
- She and Ahmet Zappa were married at the Beverly Hills mansion of Carrie Fisher.
- Graduated from the University of Michigan in 1994 (BFA in Photography).
- Was in a relationship with Jason Bleick from 2010 to 2012. They have a son together, Arthur Saint Bleick (b. July 25, 2011), who was born 21 days late and weighing in at 7 lb. 12 oz.
- Originally moved to New York to pursue photography. Her plans soon changed, however, as she wound up studying at the Stella Adler Conservatory and Column Theater.
- Her paternal grandparents were Jewish emigrants, from Poland and Russia, and her maternal grandfather was from a Jewish family from Ukraine/Russia. Her maternal grandmother was of Scottish, from Lanarkshire, and English, from Warwickshire, ancestry. Selma was raised Jewish.
- Inadvertently guest starred in the season five episode of Xena Warrior Princess, "Lifeblood" when the scenes and story from the unreleased TV Movie/Pilot "Amazon High" (made by the producers of Xena) were used as part of the episode's story line via flashbacks.
- Returned to work eight months after giving birth to her son Arthur in order to begin filming Anger Management (2012).
- Auditioned for the part of Joey in Dawson's Creek (1998).
- Wore a very large pair of fake breasts to play a stripper in the movie A Dirty Shame (2004), directed by John Waters.
- Was five months pregnant with her son Arthur when she completed filming on Dark Horse (2011).
- Was in consideration for the role of Susan Johnson in Arthur (2011), but Jennifer Garner was cast instead.
- Went to camp at Black River Farm and Ranch, a horseback riding camp for girls.
- Attended Cranbrook Kingswood School in Bloomfield, MI, at the same time as Elizabeth Berkley. Another graduate was Jaime Ray Newman.
- Was supposed to be a regular on the TV show Getting Personal (1998), but was fired after the original pilot.
- Before heading to New York, spent her freshman year (1990-91) at Kalamazoo College, where she did a play called "The Little Theater of the Green Goose" and studied photography.
- Engaged to Ahmet Zappa (October 2003)
- Was delivered via Caesarean section.
- Was invited to join the actor's branch of the Academy of Motion Picture Arts & Sciences in 2023.
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