- Remained friends with That Girl (1966) co-star Ted Bessell until his death. Thomas insisted Bessell see a doctor (which he did), when he complained of chest pains only days before he died.
- St. Jude Children's Research Hospital national outreach director.
- Her sister Terre Thomas, her brother Tony Thomas and her father Danny Thomas all appeared on the That Girl (1966) episode, My Sister's Keeper (1969).
- Attended and graduated from the University of Southern California with a teaching degree.
- Her father was of Lebanese descent and her mother was of Italian origin. Her mother's maiden name was Rose Marie Cassaniti.
- Future successful television producer Aaron Spelling wrote the script for one of her very earliest television roles, an appearance with her father Danny Thomas on the anthology series Zane Grey Theatre (1956) telecast on February 2, 1961: Honor Bright (1961).
- She studied drama at HB Studio in Greenwich Village, New York City.
- Thomas and Donohue, long-time residents of Westport, Connecticut sold their sprawling Long Island Sound estate for close to its asking price, just under $30 million, moving to a smaller property across town. (December 2006)
- Godmother is Loretta Young.
- She was a member of the Kappa Alpha Theta sorority.
- She was awarded the Presidential Medal of Freedom by President Barack Obama on November 24, 2014, the highest honor bestowed upon a civilian, at a White House ceremony.
- Best known by the public for her starring role as the wholesome Ann Marie on That Girl (1966).
- She was awarded the Women in Film Lucy Award for her excellence and innovation in her creative works that have enhanced the perception of women through the medium of television (1996).
- Is the eldest of three children of Danny Thomas and Rose Marie Mantell Thomas.
- Attended and graduated from Marymount High School in Los Angeles, California (1956).
- She was awarded a Star on the Hollywood Walk of Fame for Television at 6902 Hollywood Boulevard in Hollywood, California on December 3, 1992.
- The book "That Girl and Phil" (1991) by Desmond Atholl describes the love story of Marlo Thomas and Phil Donahue.
- Was repeatedly a comedic target of the Will & Grace (1998) character Karen Walker, who hated her, but liked her husband, Phil Donahue.
- Lifelong friends with feminist leader Gloria Steinem.
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