- (On his friendship with partner and collaborator, Matt Stone): "If anything, the friendship becomes greater because you share something special together that you don't share with your other friends".
- Cartman is the proverbial fat kid who everyone picked on, but he still hangs out all the time. His voice just sort of came from...doing Stan's voice but putting a lot of fat on it.
- (On Team America: World Police (2004)): "It's like a Bruckheimer musical".
- (On That's My Bush! (2001)): "A lot of people didn't get it. I didn't get it myself".
- During the run we were like, "So there's two things we can't do on Comedy Central: Show Mohammed or Tom Cruise."
- "You know, everyone says that South Park (1997) is satire and political satire and whatever, but really when you look at a season, there's rarely more than a couple episodes per season that are political satire".
- Winning the Emmy really was like, you're kind of the punk rock kid at school, and suddenly you get Student of the Month. And you're like, "This isn't cool."
- [Spotlight on location's interview in the Baseketball special features] We laugh at everything and make fun of everything and as soon as we say "we're not gonna make fun of this" then we become racists and bigots and whatever we call us.
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