- Became a "born again" Christian while working on the show Growing Pains (1985). He admits that his religious beliefs put him at odds with the show's writers and that he flatly refused to do parts of the scripts as presented, but was willing to work around or to edit the offensive content.
- Parents named him after Captain Kirk, the William Shatner character from the original Star Trek (1966) series.
- His acting mentor, and one of his best friends, was Growing Pains (1985) co-star Alan Thicke. He served as a pallbearer at Thicke's funeral.
- Received no financial compensation whatsoever for acting in Fireproof (2008), and does not accept any royalties from the film.
- Has six children, four of whom were adopted: Jack (b. 1996), Isabella (b. 1998), Anha (b. 1999), and Luke (b. 2000); and two biological: Olivia Rose (b. 7/18/01) and James Thomas Cameron (b. 4/13/03).
- Once appeared on sister Candace Cameron Bure's show, Full House (1987), in the episode, Just One of the Guys (1988), in 1988.
- He and wife, Chelsea Noble, are among the founders of Camp Firefly and The Firefly Foundation, which sponsors camping trips for terminally-ill children and their families.
- Met his wife, Chelsea Noble, on the set of Growing Pains (1985).
- Brother of Candace Cameron Bure, Bridgette Cameron and Melissa Cameron.
- Now a Christian evangelist, with Ray Comfort, in "The Way of the Master" organization.
- Ranked #15 in VH1's list of the "100 Greatest Kid Stars".
- Began acting at the age of nine, appearing in television commercials and guest roles. His first starring role was at the age of 13 in the series Two Marriages (1983).
- Ranked #19 in "TV Guide"'s list of "TV's 25 Greatest Teen Idols" (1/23/05).
- Co-created the Crocoduck.
- He has Scottish, German, English, Irish, and smaller amounts of Jersey (Channel Islander) and Dutch, ancestry.
- Brother-in-law of Valeri Bure and John Ridenour.
- His father is Robert Cameron and his mother is Barbara Cameron.
- Mentioned in Are You There God? It's Me, Peter (2018),.
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