- Was in a relationship with Matthew Perry from 2006-2012.
- She graduated from the prestigious Hamilton Academy of Music in Los Angeles, California, Class of 2000. Her classmates included actor Emile Hirsch.
- Her mother died of illness when she was 13 years old.
- Grew up in a Reform Jewish family. Her ancestors were from Latvia, Austria, Lithuania, and Russia.
- Godmother of Busy Philipps's daughter Birdie Silverstein.
- Has a cat named Lisa Turtle.
- Married her boyfriend of 2 years Tom Riley in Italy over Labor Day weekend following a 16-month-long engagement. (September 2017)
- In 2003 she named her (male) cat Colbert, after Stephen Colbert, who at that time was a correspondent on The Daily Show (1996). As of May 2016, that cat was still alive.
- Loves the show Saved by the Bell (1989).
- Named one of Variety's Top 10 Actors to Watch 2006.
- Lives in the Hollywood Hills.
- She is the godmother of the daughter of actress Busy Philipps and screenwriter Marc Silverstein.
- Played Ami in the romantic comedy My Best Friend's Girl (2008). (October 2007)
- Her first cousin, once removed, is publicist Howard Bragman.
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