- Brother of Cecil B. DeMille
- He had two daughters with Anna: Agnes de Mille and Peggy George.
- First wife, Anna George, was the daughter of the economist Henry George, author of "Progress and Poverty".
- Father-in-law of B.P. Fineman, brother-in-law of Constance Adams.
- Fathered Richard de Mille out of wedlock with actress Lorna Moon. Richard was adopted by his married brother, director Cecil B. DeMille, and his wife Cecilia.
- President of the Academy of Motion Picture Arts and Sciences from 1929-31.
- Alumnus of the AADA (American Academy of Dramatic Arts), Class of 1901.
- De Mille became a drama instructor at USC when his filmmaking career went into decline. One of his students there (and one with whom he often clashed) was a young Sam Peckinpah.
- Hosted the very first Academy Awards in 1929 alongside Douglas Fairbanks and again in 1930
- Son of Beatrice DeMille and Henry C. DeMille.
- His father, Henry Churchill deMille, was born in Washington, Beaufort, North Carolina, and had English, German, Scottish, and Dutch ancestry. His mother was born Matilda Beatrice Samuel in Liverpool, Lancashire, England, to a German Jewish family.
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