- Father of actresses Emily Deschanel and Zooey Deschanel.
- Born to a French father and an American mother, who raised him in her Quaker religion.
- Father-in-law of David Hornsby.
- Graduated from USC School of Cinema-Television (1968)
- Attended Johns Hopkins University before USC film school.
- Co-founder of Dark Light Pictures, W. Hollywood, CA, circa 1994
- Member of the Board of Governors of the Academy of Motion Picture Arts and Sciences (Cinematographers Branch) [2003-]
- Grandfather of Henry Hornsby.
- Member of the American Society of Cinematographers (ASC) since 1984.
- Ex-father-in-law of Benjamin Gibbard.
- Worked as a camera operator for Wakefield Orloff and Paisley productions.
- Was the original director of photography on Titanic (1997), but after creative differences with director James Cameron, he was replaced by Russell Carpenter.
- Was a member of American Zoetrope Studios in San Francisco.
- Caleb Deschanel was nominated for a 2019 Academy Award in the Best Cinematography category for his work on Never Look Away (2018) but lost to Alfonso Cuarón for Roma (2018).
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