- Father of Nayib Estefan (born 1980) and Emily Marie Estefan (born 1994).
- Was 15 when he immigrated from Cuba to Miami.
- On February 13, 1998, he and with his wife, Gloria Estefan, won the court case for the right to use the name Bongo Cuban Cafe for the cafe they own in Disney World. They were sued by makers of Bongo blue jeans for trademark infringement.
- Uncle of Spanish-language talk-show host/celebrity Lili Estefan.
- He was awarded a Star on the Hollywood Walk of Fame for Recording at 7021 Hollywood Boulevard in Hollywood, California on June 9, 2005.
- Bought a minority ownership stake in the Miami Dolphins with his wife on June 22, 2009.
- Although born in Cuba, he has Lebanese ancestry.
- Founded The Miami Sound Machine.
- Received the Sammy Cahn Lifetime Achievement Award by the American Songwriters Hall of Fame and the Ellis Island Metal of Honor (2009).
- Mentor to Shakira.
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