- She is the first cast member of Saturday Night Live (1975) to be pregnant while on the show.
- Although she used a mock shrill, off-key singing voice while paired up hilariously with music teacher "husband" Will Ferrell on SNL, Ana actually possesses an incredible vocal instrument and wowed them in a 2005 Chicago production of "Wicked" as the Wicked Witch, and, more recently, as Mrs. Peachum in "The Threepenny Opera" on Broadway.
- performing as Elphaba the wicked witch in the Broadway production of "Wicked" (October 2006)
- Used to be friends with President Jimmy Carter's daughter, Amy Carter, while the Carter family lived in Washington, D.C. She once even played the violin for Anwar Sadat, former president of Egypt.
- August 2002: Announced that she would not be returning for a new season of Saturday Night Live (1975). She had been on the show for 6 years.
- In Mean Girls (2004), she played a tenured professor at her real-life alma mater, Northwestern University.
- Her father, Phil Gasteyer, is the mayor of Corrales in New Mexico where he and Ana's mother, Mariana (an artist), moved in their retirement.
- Earned her bachelor of science in speech, theater, and performance studies at Northwestern University, in Evanston, IL.
- Ana delivered a 9 pound, 1 ounce baby girl named Frances Mary McKittrick in June 2002.
- She revealed in an episode of the National Public Radio program "Wait Wait... Don't Tell Me" that her audition for Saturday Night Live (1975) included impressions of an NPR talk radio host (similar to the character in the famous "Delicious Dish" sketch), Martha Stewart and Cokie Roberts.
- Her first name is pronounced "On-uh". Surname is pronounced "gas-tire".
- Portrayed Hillary Clinton on Saturday Night Live (1975).
- Gave birth to a son, Ulysses McKittrick, in March, 2008.
- Currently starring as Elphaba in the Chicago production of "Wicked". (July 2005)
- Playing "Mrs. Peachum" in the new Broadway revival of "Threepenny Opera", translated by Wallace Shawn. (March 2006)
- She was nominated for a 2008 Joseph Jefferson Award for Actress in a Principal Role in a Musical for "Passion" at the Chicago Shakespeare Theater in Chicago, Illinois.
- Graduate of Sidwell Friends High School (alma mater of Chelsea Clinton).
- She was nominated for a 2005 Joseph Jefferson Award for Actress in a Principal Role in a Musical for "Wicked!", at the Broadway in Chicago-Wicked Chicago Theatre in Chicago, Illinois.
- Involved in Paul Warshauer's improvisational comedy, "Me-Ow", show at Northwestern University.
- Her father has German and English ancestry and her mother is the daughter of Greek and Romanian parents.
- Her first-ever appearance was in a repeated segment of the short-lived PBS show Powerhouse (1982). The clip asked who is a friend. Her answer? Someone you can be weird with.
- Friends with Ken Jeong.
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