- Daughter of Kelsey Grammer and Doreen Alderman.
- Named after her ill-fated aunt who was raped and murdered eight years before she was born. Her middle name, Karen, is the same as her late aunt's first name.
- Once had an alpaca named Frasier; now has a cat named Cookie.
- Mother, Doreen Alderman, was a back-up dancer (dressed in green) in Steve Martin's Saturday Night Live (1975) King Tut skit.
- Has a son, Emmett Emmanual Hesketh (b. October 10, 2011 weighing in at 7 lbs. 7 oz), with her now ex-husband James Hesketh.
- Wanted to be a zoologist as a child.
- Younger half-sister, Greer Grammer, was Miss Teen Malibu 2008.
- Has six younger half-siblings through her father Kelsey Grammer: Greer Grammer (b. February 15, 1992), Mason Olivia Grammer (b. October 24, 2001), Jude Gordon Grammer (b. August 28, 2004), Faith Evangeline Elise Grammer (b. July 13, 2013), Kelsey Gabriel Elias Grammer (b. July 22, 2014) and Auden James Ellis Grammer (b. November 14, 2016). Another younger half-brother, Faith's twin, died inter uterine.
- Studied art history at Marymount Manhattan before switching to theater.
- Attended college at Marymount Manhattan.
- Attended Los Angeles County High School for the Arts.
- (November 30, 2017) Her husband of 6 years James Hesketh has filed for divorce from her.
- One of her favorite movies is Annie Hall (1977).
- When she was 10 years old, she had a crush on Jonathan Taylor Thomas.
- Ex-stepdaughter of Camille Grammer.
- Engaged to James Hesketh [January 25, 2011].
- Stepdaughter of Kayte Grammer.
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