- His son, Stefan Holt, anchors the morning news in Chicago, where Lester used to be an anchor. On November 23, 2012, when visiting his son for Thanksgiving, Lester co-anchored the NBC morning news in Chicago with his son.
- His father is African-American, his mother is of Jamaican, Indian, English, and Scottish descent.
- Plays the bass guitar.
- Former Anchor/Reporter for WBBM Channel 2, the CBS affiliate in Chicago, IL.
- Anchor on MSNBC (November 2000)
- Father of son Justin Holt.
- Grandfather of Henry Holt, and Samuel Holt.
- Began as the NBC Nightly News Anchor in 2015.
- Gave the commencement speech at Villanova University on 19 May 2023.
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