- For his "appearance" on The Simpsons (1989), he was depicted with a paper bag over his head.
- Famously reclusive - all known photos of him date from the early 1950s.
- The mysterious Yoyodyne corporation that appears in or in The Crying of Lot 49 and V. has appeared, often as references and in-jokes, in various TV series and movies, such as Star Trek: The Next Generation (1987) (as manufactors of starship parts), More Changes (1995), Angel (1999), Silicon Valley (2014) and The Adventures of Buckaroo Banzai Across the 8th Dimension (1984).
- Uncle of Tristan Taormino.
- Reclusive American author best known for his epic novels "Gravity's Rainbow," "V." and "Mason & Dixon.".
- Attended lectures by Vladimir Nabokov while an undergraduate at Cornell University, to the extend that Nabokov's wife Vera Evseevna Slonim claimed she recognized his writing style in the essays Nabokov corrected.
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