Has one daughter, Varvara Moroz (b. November 4, 2015), with her husband Yuriy Moroz. They revealed their daughter's birth only in November 2018, when she was 3.
Her first daughter with Yuriy Moroz died in 2003 at 3 months old due to complications of her parents genetic incompatibility. Isakova and Moroz later solved the problem of their genetic incompatibility, and had another daughter, Varvara.