- Was educated at Clifton College and Trinity College, Dublin where he studied modern languages.
- From 2005 until his death he served as the honorary president of the Bristol Hospital Broadcasting Service, a registered charity which provides a radio service to the hospitals of Bristol.
- Was president of the Atwell-Wilson Motor Museum.
- On radio, he was the regular host of Pick of the Week between 1981 and 1988, and a frequent guest presenter until 2006.
- Serle also presented the viewer-response show Points of View, The Computer Programme, and Monkey Business.
- Serle featured on an episode of the BBC game show, The Adventure Game, with Sandra Dickinson and Adam Tandy on 16 February 1984.
- He was also the interviewer and host of the BBC series Greek Language and People with Katia Dandoulaki.
- Serle presented the first series of the ITV gameshow Runway (1987).
- In the 1980s, he presented Windmill in which clips from the BBC archives on particular themes were shown (so called as the then base for BBC archives was in Windmill Road, Brentford).
- Chris Serle was a British television presenter, reporter, and actor.
- He appeared as a foil for Irish comedian Dave Allen in his series Dave Allen at Large in 1971.
- In 2001 he sailed on two legs of the Global Challenge Round the World yacht race including a gruelling 6,000-mile trip from Buenos Aires, around Cape Horn and across the Southern Ocean to New Zealand.
- Chris Serle presented a series in which he, and fellow former That's Life! presenter Paul Heiney, were pitched into professional situations with no prior knowledge in In at the Deep End.
- Serle gained great UK public recognition as one of the presenters on the TV series That's Life.
- In 1969 he joined the BBC as a radio producer.
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