- Attended and graduated from NJ's West Windsor-Plainsboro HS, class of 1988. Classmate of Ethan Hawke.
- He was thirty-five years old when he made his first album.
- In 2003, Murphy worked with pop singer Britney Spears on her album In the Zone, but the collaboration was unsuccessful.
- Murphy participated in Canon's Project Imaginat10n, which called for 5 celebrities to direct short films based on pictures uploaded by people around the world to the Project Imaginat10n site. The result was "Little Duck", Murphy's first directorial effort. Ron Howard advised Murphy in his directing. Shooting took place in Japan, the setting of the film.
- In collaboration with coffee company Blue Bottle, Murphy created his signature coffee called House of Good. It is described as a "syrupy, well-balanced and thoroughly accessible" espresso. It was developed with help of Blue Bottle founder James Freeman.
- Collaborating with IBM, James Murphy "remixed" the 2014 US Open matches. Murphy composed an algorithm that generated pieces from the sounds and occurrences, such as fault, point and ace for example, of the actual matches. Murphy cut his favorite moments from the pieces and created 14 remixes from them.
- Murphy opened a wine bar named Four Horsemen in June 2015 in Williamsburg, Brooklyn, selling a range of natural red, white and orange wines.
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