- Striker for Danubio F.C. (2006), S.S.D. Palermo (Italy, 2007-2010), S.S.C. Napoli (Italy, 2010-2013), Paris Saint-Germain (France, 2013-2020), Manchester United F.C. (England, 2020-2022), Valencia C.F. (Spain, 2022-23) and Boca Juniors (Argentina, 2023-).
- Honours with Danubio F.C.: Uruguayan Primera División (2007). Honours with S.S.C. Napoli: Coppa Italia (2012). Honours with Paris Saint-Germain: 5x Ligue 1 (2014-2016, 2018 & 2019); 5x Coupe de la Ligue (2014-2018); 4x Coupe de France (2015-2018); 3x Trophée des Champions (2014, 2015 & 2017).
- International with Uruguay National Football Team since 2008. Member of the Copa América 2011, 2015, 2016, 2019, 2021, and the South Africa '10, Brazil '14 and Russia '18 squads.
- Was named in the Team of the Year of the Serie A (2011, 2012, 2013) and the Ligue 1 (2014, 2017, 2018).
- Father of, with his ex-wife Soledad Cabris, Bautista (b. 2011) and Lucas (b. 2013).
- Member of the Uruguay National Football Team who won the 2011 Copa América.
- Top Scorer of Coppa Italia (2012), Serie A (2013), Ligue 1 (2017, 2018), Coupe de la Ligue (2014, 2015, 2017), Coupe de France (2015) and FIFA World Cup qualification (2018).
- Has been in a relationship with Jocelyn Burgardt since 2013.
- Was romantically linked to María Rosario Ventrone, Micaela Orsi and Sofía Suescun.
- Scored the 1:0 goal for Napoli against Juventus F.C. during the final match of Coppa Italia 2012.
- Named the UNFP Ligue 1 Player of the Year in 2017.
- Named in the ESM Team of the Year in 2017.
- Won the Golden Foot award in 2018.
- Father of, with Jocelyn Burgardt, India Cavani (b. May 2019) and Silvestre (b. June 2021).
- Scored goals for Paris Saint-Germain during the finals matches of Coupe de la Ligue (2014, 2015, 2017, 2018), Coupe de France (2015, 2016, 2018) and Trophée des Champions (2015).
- Paris Saint-Germain's all-time top scorer (200 goals).
- Named in the UEFA Europa League Squad of the Season in 2021.
- Played well over 600 games at Europe.
- Scored well over 350 goals at Europe.
- Broken Antonio Vojak record on the S.S.C. Napoli's list of the all-time top goalscorers with 104 goals.
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