Muriel Buck Humphrey was born on 20 February 1912 in Huron, Beadle County, South Dakota, USA. She was married to Max Brown and Hubert H. Humphrey. She died on 20 September 1998 in Minneapolis, Minnesota, USA.
At the time of her death, in addition to son Hubert H. Humphrey III; she had a daughter, Nancy Humphrey Solomonson; two additional sons, Robert Humphrey and Douglas Humphrey; 12 grandchildren; and 3 great grandchildren. From her second marriage, she was also the step-mother of two adult children, and grandmother to 5 more grandchildren.