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This is a nice, efficient mystery/thriller, enlivened by the presence of Boris Karloff and Edward van Sloane. Karloff is fine in this non-monster role, as a cocky, bowler wearing, cigar smoking crook. His presence (in retrospect) also provides a cachet of horror to the mix. This movie, after all, was shooting just as Frankenstein was released. The rest of the cast is very good and the direction is no-nonsense, straight ahead story telling (if a bit improbable). Things keep moving so quickly you don't really have time to question the plot's realism. But the real kick and revelation is Edward van Sloane in a dual/triple role -- in particular, his portrayal of Dr. Steiner, with his crackling electronic gear, his google-eye specs, his trilling foreign accent -- apparently having the time of his life as an sinister, conniving doctor masterminding a dope ring. His sadistic banter during the film's climax is convincing enough to rank with the best of Lionel Atwill's or Bela Lugosi's incarnations of mad doctors at the height of their madness.