No Holds Barred finds the Bowery Boys involved in the wrestling game when a magic spell gives Huntz Hall a kind of reverse Achilles situation. Instead of only one spot on his body being vulnerable, Hall has one spot of invulnerability. The only problem is that it periodically relocates without any warning.
With Leo Gorcey managing Hall and the ever exasperated Bernard Gorcey allowing them to use Louie's Sweet Shop as a training gym, one Horace DeBussy Jones becomes heavyweight champion of the world. But the forces of evil want to bring him down.
Visiting from the Life Of Riley are Marjorie Reynolds who tries to vamp the secret of his success out of Huntz Hall and Henry Kulky who trains him in some basic wrestling maneuvers.
Where does the power end up, literally in the end.