A world famous pianist loses his hands as the result of a car crash, and is then given the hands of a killer in an audacious medical transplant. This event has a dark psychological effect on him.
Hands of a Stranger is a little too talky for its own good. The story itself might be a well-worn one but there's no excuse for the serious lack of action here. An 'evil hands' film really needs to cut back on the chat and deliver more schlock. There are occasional memorable moments such as the scene where the pianist visits the home of the taxi driver responsible for the crash that maimed him but in the main such sequences are in short supply. The lead character Vernon is also a somewhat hard character to get behind. His ingratitude for the surgery that prevented him from being without hands marks him out as a somewhat arrogant and unsympathetic individual.
One reasonably interesting aspect of the film is that its quite ambiguous for a movie of this type, in that it is never really made certain that the hands are inherently evil or not. It seems to me that the surgery merely effects the natural dexterity that Vernon had, and as a result makes him unable to play piano, leading to psychological breakdown. In this sense Hands of a Stranger is quite interesting. But its poor pacing and lack of action mean that it is not enough to save it from being a bit of a clunker.