This is by no means a masterpiece, but with its budget it's a pretty decent flick. The plot is that a model drinks a drug that makes her immune to the toxin that is slowly killing the planet. You never know who is good or bad, they all want some piece of her. That ambiguity is the best piece of the film. The acting of the main characters is not bad, but most side characters are amateurish South Africans and it shows. The effects are decent too, although they are not a lot.
Clancy Brown is just cameoing in this film, so him being top billed to get people to watch this does not sit well with me. The main character is played by Grace Van Dien, and she is both beautiful and a good actress. Everybody else is mostly unknown. The end scene was kind of dumb, as well as the identity of Lazarus. The ending is also hinting at a possible sequel.
Bottom line: not something I would recommend, but a good effort.
Now the rest is slightly spoilery, so continue only if you've seen the film.
The premise of the film is that people (and everything else) are dying from an environmental toxin that we can only presume is the result of human action, but the two sides trying to solve the problem either want to sell a temporary antidote only for the "worthy" or to make everybody a different species in order to survive. The first assumes they know better and the latter that humanity, reaching this point, will not continue to be idiotic. In a way, that does make the villain camp more credible, adding to the fun of figuring out which faction one would agree with, but it also detracts from the natural desire of viewers to side with someone. I am not sure the writer saw it that way, so it may only be an involuntary achievement. You decide.