Brian Finch develops superhuman abilities after taking a mysterious drug called NZT, which finds him landing on the FBI's radar as he works to clear his name of an NZT-related murder.
Brian helps Agents Harris and Boyle investigate the murder of a retired FBI agent and is shocked to find a link to the elusive head of a notorious drug cartel. Also, Brian reconnects with an old flame.
Brian's loyalty to the FBI is tested when Sands demands he steal the FBI's secret files on NZT; Rebecca is emotionally conflicted when she learns what her estranged father left her following his death.
Brian learns a shocking secret about Rebecca's late father and accidentally meddles in her personal life while learning self-defense from her secret boyfriend, FBI Agent Casey Rooks.
When Naz is detained on suspicion of funding terrorism, Brian and Rebecca's efforts to clear her name lead them to Naz's daughter, Ava, who reveals a family secret Naz has kept from the FBI.
Boyle's old friend from the service claims someone hacked his prosthetic arm and used it to murder his wife and frame him, so Boyle asks Brian to help prove his innocence.
When Casey and his SWAT team skim 80 NZT pills for themselves from the recovery of stolen inventory, it starts an internal investigation that is viewed through the shifting perspectives of Brian's immediate circle at the FBI.
Senator Edward Morra is targeted by a would-be assassin, and Brian is ordered to sabotage the FBI's investigation into the murder attempt in order to prevent exposing the Senator's connection with NZT.
Brian hunts down a thief who has stolen digitized copies of the world's brightest minds. Rebecca comes closer to finding the truth behind Morra's tampered jacket.
While Rebecca gets closer to discovering Brian's secret, Brian goes rogue from the FBI and goes to Russia to find the only person who can help him cut all ties from Senator Eddie Morra.
Back from Russia but under the thumb of Naz's new restrictive rules, Brian helps investigate the murder of a billionaire who's new kidney was forcibly removed.
When Rebecca learns a truth about her father's death, she takes NZT and uses it to seek justice for his murder. Sands allows a dangerous move against Brian to ensure the success of his new initiative.