This is the first Time Crisis game to feature two pedals instead of one.
This is the first Time Crisis game to have more than three stages, and receive a new cabinet containing extra stages, called the "True Mastermind Edition", making this the longest of the Time Crisis games.
So far, this is the only Time Crisis game that is currently arcade exclusive and has yet to get a console port.
This is the first Time Crisis game where Wild Dog is the boss at the end of the first three stages.
This is the first Time Crisis game to use the Unreal Engine.