A scene in the movie features a poster of this film's director A.R. Murugadoss' previous film, Ghajini (2008). Similarly, in the scene that follows, the same film is playing in the background of a cinema hall. The same cinema hall features a poster of Khaidi No. 150, the 2017 film which is a remake of another film by Murugadoss, Kaththi (2014).
Spyder is the first bilingual (Telugu & Tamil) film for Superstar Mahesh Babu.
Mahesh returned his remuneration as the movie incurred losses.
This movie is heavily inspired from Christopher Nolan's ' the dark knight'
Though his role is brief, this also marks Telugu actor, Priyadarshi Pulikonda's Tamil debut.
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