Bonnie Dennison played Jenny in the pilot, but the role was recast, and she was replaced by Ashley Tisdale.
Despite having a devoted fan base and good reviews, CBS officially declined in May 2020 to renew Carol's Second Act (2019) for a second season, reportedly because of inconsistent week-to-week ratings.
Writer Emily Halpern previously wrote for another medical series, Private Practice (2007). Neither of the head writers are doctors.
The show was taped in front of a live studio audience.
The series finale, R.I.P. Dr. Herman (2020), aired the night after the World Health Organization officially declared COVID-19 a pandemic. The following week, most non-essential workers around the world, especially in the United States, were ordered to stay home.
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