One of the episodes has Danny traveling through the town of Mayberry, and introduces Andy Griffith as Sheriff Andy Taylor: Danny Meets Andy Griffith (1960). It was then spun-off into the series The Andy Griffith Show (1960)
Penney Parker beat a then-unknown actress named Mary Tyler Moore for the role of Terry. According to Danny Thomas, the only reason Parker got the part was because he felt Moore's nose looked different enough from his so that nobody would believe she was his daughter.
Danny Thomas and Marjorie Lord appeared as their same characters, Danny and Kathy Williams, in The Lucy-Desi Comedy Hour (1957), in "Make Room for Danny" (first aired on December 1, 1958). Rusty Hamer and Angela Cartwright also appeared as their characters, Rusty and Linda Williams.
Danny Thomas was forced against his will to have Jean Hagen as his television wife. He could not stand her attitude, or what he considered her slovenly appearance. During one rehearsal, he is said to have have shouted, "For God's sake, Jean, put on a little lipstick." She left after the third season, and at the beginning of the fourth season, to assure that she could not come back, he had her character die.
The theme song was a jazzed-up version of the old Irish tune The Londonderry Air (best known when sung with the lyric known as "Danny Boy").