Tom chases Jerry around a high-rise apartment, and out onto the perilous ledge that surrounds it.
'Ah, Sweet Mouse-Story of Life' sees director Chuck Jones taking Tom and Jerry into Roadrunner territory, with an extremely simple chase scenario and surreal humour (both the title scene, with Tom revving up like a car to chase the mouse, and the first 'falling wall' gag, are classic Wile.E.Coyote-style gags).
While the sight of Jerry grabbing onto a question mark to save his life, or pulling daggers from his thought bubbles to throw at Tom, are undeniably inventive, these ideas really aren't in keeping with the series' established approach, which makes this one only partially successful as far as I am concerned.