There actually are stones known as "trovants" in Romania, that grow, move, and even reproduce. They take in the minerals from the rain after each heavy downpour, which combine with the chemicals already existing in the rock to produce a reaction and pressure within that eventually causes the stone to grow and reproduce.
The meteor crash is footage of the spaceship crash from It Came from Outer Space (1953) which Universal produced four years earlier.
The "town" of San Angelo is actually the Universal Studios back lot, the "Courthouse Square Lot" to be specific. It's the same lot used in 1985's "Back To The Future" and it's buildings/courthouse are highly memorable.
William Schallert has an uncredited role as the US Weather Bureau forecaster.
The only movie monster to be a purely chemical process.